An Efficient Method for the Preparation of Benzylic Bromides

Peinian Liu; Yingchun Chen; Jingen Deng; Yongqiang Tu

doi:10.1055/s-2001-18060

SHORTPAPER

An Efficient Method for the Preparation of Benzylic Bromides

Peinian Liu^a, Yingchun Chen^b, Jingen Deng*^b, Yongqiang Tu^a
^a Department of Chemistry & National Laboratory of Organic Chemistry, Lanzhou University, Lanzhou 730000, China
^b Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, the Chinese Academy of Sciences, Chengdu 610041, China
Fax: +86(28)5223978; e-Mail: jgdeng@cioc.ac.cn;

Abstract

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Abstract

Substituted benzylic compounds are brominated with an excess of N-bromosuccinimide (NBS) in CCl₄ to the corresponding polybrominated mixtures which are then debrominated with diethyl phosphite and N,N-diisopropylethylamine to afford the desired monobromides in satisfactory yields and high purity.

Key words

debromination - benzylic bromides - diethyl phosphite - N,N-diisopropylethylamine

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References

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